Traditional knowledge for climate change adaptation in Mesoamerica : a systematic review

This research was carried out during the first author's postdoctoral research (CVU number 292956 ) funded by the Consejo Nacional de Ciencia y Tecnologia (CONACYT) Mexico.Indigenous and rural peoples have developed close connections with land and nature for millennia. Traditional and local knowledge resulting from such human-environment interactions is embedded in ethnic, linguistic, and cultural contexts, and may assist local communities in adapting to global issues such as climate change. However, the extent to which traditional knowledge supports adaptation to local manifestations of severe socio-environmental changes, the traditional knowledge techniques that play an effective role in adaptation, and the dynamic yet integral aspect of traditional knowledge for indigenous and mestizo cultures remain unclear. Despite an extensive literature on climate change, adaptation, and traditional knowledge in the Global South, Mesoamerican countries are underrepresented. The aims of this systematic review were to address the main manifestations of climate change in Mesoamerican countries, to critically analyze relationships between traditional knowledge and contemporary climate change adaptation and to make recommendations regarding knowledge conservation, production, and exchange for climate change adaptation in the region. We systematically identified, reviewed, and coded 77 relevant papers. Our results show that: 1) most papers do not distinguish between local, traditional, and indigenous knowledge; 2) rainfall variability, droughts, and weather unpredictability are the most frequently expressed experiences of climate change; 3) the main adaptations undertaken by smallholders are changes to the agricultural calendar and crops cultivated, a shift to more sustainable agriculture, and labour diversification to generate off-farm income; and 4) many more articles are published on Mexico than the other Mesoamerican countries, and predominantly by authors from outside Mesoamerica. Local traditional knowledge makes important contributions to climate change actions and policy by observing changing climates, adapting to impacts, and contributing to global mitigation efforts. As a response to increasing climate change challenges, smallholders create new hybrid knowledge by combining traditional and western perspectives. This knowledge evolution will support greater resilience to climate change but may hasten cultural erosion and exacerbate social inequalities in the region unless efforts are taken to maintain cultural integrity.Publisher PDFPeer reviewe

Development and implementation of a vehicle-pedestrian conflict analysis method: Adaptation of a vehicle-vehicle technique

This paper examines the development, use, and evaluation of a new traffic conflict analysis technique that specifically addresses pedestrian-vehicle conflicts with the intention of being applicable to shared-space environments. The method is based on an existing, well-established, and widely used vehicle-vehicle conflict analysis technique, but is adapted to consider the movement of pedestrians, which differs significantly from that of vehicles. The new method is then implemented on the Exhibition Road site of West London with the use of video data collected from locations with a potentially high concentration of vehicle-pedestrian conflicts, and the results of the analysis are presented. Finally, the results are compared with those obtained by other conflict analysis techniques and also against accident data to assess not only the accuracy but also the functionality of the new technique

Evaluación de un carbón activado comercial en la remoción del colorante DB2

Los colorantes sintéticos usados en la fabricación de textiles son una clase importante de compuestos orgánicos que, con frecuencia, se encuentran en los cuerpos de agua, como resultado de su amplio uso industrial, convirtiéndose en agentes que desafortunadamente afectan el medio ambiente. La disposición final de estos colorantes a los recursos de agua se debe evitar o minimizar; para tal efecto, se utilizan varias técnicas de tratamiento, siendo la adsorción una de las más empleadas. En este estudio se removió el colorante azul marino directo 2 en disolución acuosa sobre carbón activado granular comercial a 22°C ± 1°C. Se realizaron experimentos por lote para determinar el efecto de la concentración inicial (7 – 65 mgL-1) y del pH (5,0 – 9,0) sobre la capacidad de adsorción y el porcentaje de remoción. Los datos experimentales se ajustaron a los modelos de isotermas de adsorción de Freundlich y Langmuir. La capacidad de adsorción máxima lograda por el carbón activado fue de 2,22 mgg-1 a pH 5,0.

Disparities in rheumatoid arthritis disease activity according to gross domestic product in 25 countries in the QUEST–RA database

OBJECTIVE: To analyse associations between the clinical status of patients with rheumatoid arthritis (RA) and the gross domestic product (GDP) of their resident country. METHODS: The Quantitative Standard Monitoring of Patients with Rheumatoid Arthritis (QUEST-RA) cohort includes clinical and questionnaire data from 6004 patients who were seen in usual care at 70 rheumatology clinics in 25 countries as of April 2008, including 18 European countries. Demographic variables, clinical characteristics, RA disease activity measures, including the disease activity score in 28 joints (DAS28), and treatment-related variables were analysed according to GDP per capita, including 14 "high GDP" countries with GDP per capita greater than US$24,000 and 11 "low GDP" countries with GDP per capita less than US$11,000. RESULTS: Disease activity DAS28 ranged between 3.1 and 6.0 among the 25 countries and was significantly associated with GDP (r = -0.78, 95% CI -0.56 to -0.90, r(2) = 61%). Disease activity levels differed substantially between "high GDP" and "low GDP" countries at much greater levels than according to whether patients were currently taking or not taking methotrexate, prednisone and/or biological agents. CONCLUSIONS: The clinical status of patients with RA was correlated significantly with GDP among 25 mostly European countries according to all disease measures, associated only modestly with the current use of antirheumatic medications. The burden of arthritis appears substantially greater in "low GDP" than in "high GDP" countries. These findings may alert healthcare professionals and designers of health policy towards improving the clinical status of patients with RA in all countries

2017 recommendations of the Brazilian Society of Rheumatology for the pharmacological treatment of rheumatoid arthritis

The objective of this document is to provide a comprehensive update of the recommendations of Brazilian Society of Rheumatology on drug treatment of rheumatoid arthritis (RA), based on a systematic literature review and on the opinion of a panel of rheumatologists. Four general principles and eleven recommendations were approved. General principles: RA treatment should (1) preferably consist of a multidisciplinary approach coordinated by a rheumatologist, (2) include counseling on lifestyle habits, strict control of comorbidities, and updates of the vaccination record, (3) be based on decisions shared by the patient and the physician after clarification about the disease and the available therapeutic options; (4) the goal is sustained clinical remission or, when this is not feasible, low disease activity. Recommendations: (1) the first line of treatment should be a csDMARD, started as soon as the diagnosis of RA is established; (2) methotrexate (MTX) is the first-choice csDMARD; (3) the combination of two or more csDMARDs, including MTX, may be used as the first line of treatment; (4) after failure of first-line therapy with MTX, the therapeutic strategies include combining MTX with another csDMARD (leflunomide), with two csDMARDs (hydroxychloroquine and sulfasalazine), or switching MTX for another csDMARD (leflunomide or sulfasalazine) alone; (5) after failure of two schemes with csDMARDs, a bDMARD may be preferably used or, alternatively a tsDMARD, preferably combined, in both cases, with a csDMARD; (6) the different bDMARDs in combination with MTX have similar efficacy, and therefore, the therapeutic choice should take into account the peculiarities of each drug in terms of safety and cost; (7) the combination of a bDMARD and MTX is preferred over the use of a bDMARD alone; (8) in case of failure of an initial treatment scheme with a bDMARD, a scheme with another bDMARD can be used; in cases of failure with a TNFi, a second bDMARD of the same class or with another mechanism of action is effective and safe; (9) tofacitinib can be used to treat RA after failure of bDMARD; (10) corticosteroids, preferably at low doses for the shortest possible time, should be considered during periods of disease activity, and the risk-benefit ratio should also be considered; (11) reducing or spacing out bDMARD doses is possible in patients in sustained remission

Circulating levels of insulin-like growth factor-I (IGF-I) correlate with disease status in leprosy

<p>Abstract</p> <p>Background</p> <p>Caused by <it>Mycobacterium leprae </it>(ML), leprosy presents a strong immune-inflammatory component, whose status dictates both the clinical form of the disease and the occurrence of reactional episodes. Evidence has shown that, during the immune-inflammatory response to infection, the growth hormone/insulin-like growth factor-I (GH/IGF-I) plays a prominent regulatory role. However, in leprosy, little, if anything, is known about the interaction between the immune and neuroendocrine systems.</p> <p>Methods</p> <p>In the present retrospective study, we measured the serum levels of IGF-I and IGBP-3, its major binding protein. These measurements were taken at diagnosis in nonreactional borderline tuberculoid (NR BT), borderline lepromatous (NR BL), and lepromatous (NR LL) leprosy patients in addition to healthy controls (HC). LL and BL patients who developed reaction during the course of the disease were also included in the study. The serum levels of IGF-I, IGFBP-3 and tumor necrosis factor-alpha (TNF-α) were evaluated at diagnosis and during development of reversal (RR) or erythema nodosum leprosum (ENL) reaction by the solid phase, enzyme-labeled, chemiluminescent-immunometric method.</p> <p>Results</p> <p>The circulating IGF-I/IGFBP-3 levels showed significant differences according to disease status and occurrence of reactional episodes. At the time of leprosy diagnosis, significantly lower levels of circulating IGF-I/IGFBP-3 were found in NR BL and NR LL patients in contrast to NR BT patients and HCs. However, after treatment, serum IGF-I levels in BL/LL patients returned to normal. Notably, the levels of circulating IGF-I at diagnosis were low in 75% of patients who did not undergo ENL during treatment (NR LL patients) in opposition to the normal levels observed in those who suffered ENL during treatment (R LL patients). Nonetheless, during ENL episodes, the levels observed in RLL sera tended to decrease, attaining similar levels to those found in NR LL patients. Interestingly, IGF-I behaved contrary to what was observed during RR episodes in R BL patients.</p> <p>Conclusions</p> <p>Our data revealed important alterations in the IGF system in relation to the status of the host immune-inflammatory response to ML while at the same time pointing to the circulating IGF-I/IGFBP-3 levels as possible predictive biomarkers for ENL in LL patients at diagnosis.</p

Sinopsis epistemológica del pensamiento keynesiano: John Maynard Keynes

In the analysis of economic thought, Keynes incorporates important aspects in the study of the economy such as: the relationship between consumption and income and the multiplier, causing major changes in production; preference for liquidity, key aspect in his theory to refer to money demand, the relationship between monetary policy, the interest rate and aggregate demand; as well as the importance of expectations in consumption and investment, considering that these are a determining factor underlying the changes in demand and production. More than a treatise on economic theory explained the importance of the implications of economic policy for balance, the key factor in employment in the crisis. Following the ideas of Keynes, by which arose current debates on economic issues, a broad consensus emerged based on the integration of their approaches and economists predecessors, born here school or neoclassical synthesis, in the fifties basically with Samuelson and endless e authors refer in this essay.En el análisis del pensamiento económico, Keynes incorpora aspectos relevantes en el estudio de la economía tales como: la relación entre el consumo y la renta y el multiplicador, lo que provoca mayores cambios de la producción; la preferencia por la liquidez, aspecto clave en su teoría para referirse a la demanda de dinero, la relación entre la política monetaria, el tipo de interés y la demanda agregada; asi como también, la importancia de las expectativas en el consumo y la inversión, considerando que estos constituyen un factor determinante que subyace en las variaciones de la demanda y la producción. Más que un tratado sobre teoría económica explicaba la importancia de las implicaciones de la política económica para el equilibrio, en el empleo factor fundamental en la crisis. A raíz de las ideas de Keynes, por la cual surgieron los debates actuales en los temas económicos, surge un gran consenso basado en la integración de sus planteamientos y de los economistas predecesores, nacen aquí la escuela o la síntesis neoclásica, en los años cincuenta, básicamente con Samuelson y un sinfín e autores que se refieren en este ensayo